Endocrine Abstracts

One of the pathways of DTC dissemination is the lymphatic system, however the molecular basis of this process is still unknown. One of the key regulators of lymphangiogesis is Prospero homeobox 1 (Prox1) specifically expressed in LEC and in some human cancers. The present study investigates the expression and function Prox1 in biology of differentiated cancer cells.Studies were performed in a series of thyroid cancer FTC and PTC cell lines. Protein and t...

Podoplanin (PDPN), a mucine type transmembrane glycoprotein specific to lymphatic system is expressed in a variety of human tumors and regarded as a factor promoting tumor progression. In a recent work, we found PDPN expression in tumor cells of 40% of papillary thyroid carcinomas (PTC), however it role remains unclear. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells.PDPN gene and prot...